![]() ![]() The dose recommended for maintenance treatment is the same dose needed to stabilize patients during acute treatment healthcare providers should periodically reassess need for maintenance treatment.Dose increases of oral formulations, if needed, should be at 2-week intervals to allow time to achieve steady state.The safety of oral doses greater than 30 mg per day has not been studied.Target dose: 15 mg orally once a day may increase dose based on clinical response.Initial dose: 10 to 15 mg orally once a day.Dose increases, if needed, should be at 2-week intervals to allow time to achieve steady state.Īdjunctive Therapy with Lithium or Valproate: Use: Treatment of schizophrenia Usual Adult Dose for Bipolar Disorder Dose regimen adjustments (including addition of oral supplementation) will be needed for missed doses see dose adjustments section.Providers whose patients who experience adverse reactions with 400 mg/month extended-release IM suspension doses may consider reducing the dose to 300 mg/month.The first dose of the extended-release IM formulation should be given on the same day as the initiation/re-initiation dose providers should avoid injecting both formulations in the same deltoid or gluteal muscle.Prior to initiating therapy with extended-release IM formulations, tolerability should be established with oral formulations it may take up to 2 weeks to fully assess tolerability due to the half-life of aripiprazole.Oral formulation dose increases, if needed, should be at 2-week intervals to allow time to achieve steady state.The oral solution and oral tablets can be substituted on a mg-per-mg basis up 25 mg patients receiving 30 mg tablets should receive 25 mg of the oral solution.Re-initiation of treatment: 675 mg IM ONCE plus 30 mg of aripiprazole IR orally ONCE Maintenance doses: 441 mg, 662 mg, or 882 mg IM monthly, 882 mg IM every 4 to 6 weeks, or 1064 mg IM every 2 months this drug should not be given sooner than 14 days after the previous injection.Patients stable on aripiprazole IR at least 20 mg/day: 882 mg IM via gluteal injection ONCE PLUS aripiprazole lauroxil 675 mg IM ONCE OR aripiprazole IR once a day for 21 days.Patients stable on aripiprazole IR 15 mg/day: Initial dose 662 mg IM via gluteal injection ONCE PLUS aripiprazole lauroxil 675 mg IM ONCE OR aripiprazole IR 15 mg orally once a day for 21 days.Patients stable on aripiprazole IR 10 mg/day: 441 mg IM via deltoid or gluteal injection ONCE PLUS aripiprazole lauroxil 675 mg IM ONCE OR aripiprazole IR 10 mg orally once a day for 21 days.Maintenance dose: 300 to 400 mg IM once a month the dose should not be given sooner than 26 days after the previous injectionĪripiprazole Lauroxil Extended-Release IM Suspension:.Initial dose: 400 mg IM once continue aripiprazole IR 10 to 20 mg orally once a day for 14 days.Target dose: 10 to 15 mg per day effective dose range 10 to 30 mg per day however, clinical trials have not found doses exceeding 10 or 15 mg per day to be more effective.Īripiprazole Extended-Release IM Suspension:.Initial dose: 10 or 15 mg orally once a day.1064mg/prefilled syringe (724 mg of aripiprazole).882mg/prefilled syringe (600 mg of aripiprazole).662mg/prefilled syringe (450 mg of aripiprazole).441mg/prefilled syringe (300 mg of aripiprazole).400mg/vial or prefilled dual chamber syringeĮxtended-release injectable IM suspension (aripiprazole lauroxil ).300mg/vial or prefilled dual chamber syringe.Web-based portal for healthcare professionals and caregiversĮxtended-release injectable IM suspension (Abilify Maintena).M圜ite APP, a smartphone application (app) which is used with a compatible smartphone to display information for the patient.M圜ite patch (wearable sensor) that detects the signal from the IEM sensor after ingestion and transmits data to a smartphone. ![]() Aripiprazole tablet embedded with an ingestible event marker (IEM) sensor.Abilify M圜ite system is composed of the following components:.Tablet, embedded with ingestible event marker (IEM) sensor (Abilify M圜ite) ![]()
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